abstract：:Outcome following traumatic brain injury (TBI) is not only dependent on the nature and severity of injury and subsequent treatment, but also on constituent characteristics of injured individuals. We aimed to describe and quantify the relationship between demographic characteristics and six month outcome assessed by th...

journal_title：Journal of neurotrauma

authors： Mushkudiani NA,Engel DC,Steyerberg EW,Butcher I,Lu J,Marmarou A,Slieker F,McHugh GS,Murray GD,Maas AI

更新日期：2007-02-01 00:00:00

abstract：:Spinal cord injury (SCI) is associated with immune deficiencies and life-threatening infections. However, the specific mechanisms underlying this pathological condition remain unclear. In recent years, increasing evidence has suggested that anabolic hormones may be involved in immunological complications. Here, we mon...

journal_title：Journal of neurotrauma

authors： Rouleau P,Ung RV,Lapointe NP,Guertin PA

更新日期：2007-02-01 00:00:00

abstract：:This report is a feasibility study on the utility of gel-free proteomics in identifying peripheral biomarkers of brain injury. The study was performed in six pediatric patients admitted to the intensive care unit for severe traumatic brain injury (TBI). Serum samples collected at admission (less than 8 h after injury)...

journal_title：Journal of neurotrauma

authors： Haqqani AS,Hutchison JS,Ward R,Stanimirovic DB

更新日期：2007-01-01 00:00:00

abstract：:We conducted a study to evaluate the degree of corticospinal tract (CST) dysfunction associated with diffuse axonal injury (DAI) through analyses of both diffusion-tensor magnetic resonance imaging (DTMRI) and motor-evoked potential (MEP). Using DTMRI and MEP with transcranial magnetic stimulation, we evaluated 138 in...

journal_title：Journal of neurotrauma

authors： Yasokawa YT,Shinoda J,Okumura A,Nakayama N,Miwa K,Iwama T

更新日期：2007-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a principal cause of long-term physical, cognitive, behavioral, and social deficits in young adults, which frequently coexist with a high incidence of substance abuse disorders. However, few studies have examined the long-term effects of TBI on the neuroendocrine-immune system. TBI was ...

journal_title：Journal of neurotrauma

authors： Taylor AN,Rahman SU,Tio DL,Sanders MJ,Bando JK,Truong AH,Prolo P

更新日期：2006-12-01 00:00:00

abstract：:Injury to the spinal cord not only disrupts the functioning of spinal circuits at the site of the impact, but also limits sensorimotor function caudal to the level of the lesion. Ratings of gross locomotor skill are generally used to quantify locomotor recovery following spinal cord injury (SCI). The purpose of this s...

journal_title：Journal of neurotrauma

authors： McEwen ML,Springer JE

更新日期：2006-11-01 00:00:00

abstract：:Proton magnetic resonance spectroscopy (1H-MRS) and neuropsychological assessment were utilized in a longitudinal investigation of traumatic brain injury (TBI) in children. A spectroscopic imaging protocol was implemented, and neurometabolite ratios of NAA/Cre and Cho/Cre were calculated for anterior and posterior hal...

journal_title：Journal of neurotrauma

authors： Yeo RA,Phillips JP,Jung RE,Brown AJ,Campbell RC,Brooks WM

更新日期：2006-10-01 00:00:00

abstract：:Many patients with mild traumatic brain injury (MTBI) concurrently sustain extracranial injuries; however, little is known about the impact of these additional injuries on outcome. We assessed the impact of additional injuries on the severity of postconcussional symptoms (PCS) and functional outcome 6 months post-inju...

journal_title：Journal of neurotrauma

authors： Stulemeijer M,van der Werf SP,Jacobs B,Biert J,van Vugt AB,Brauer JM,Vos PE

更新日期：2006-10-01 00:00:00

abstract：:Clinicians are often faced with the challenging task of distinguishing between accidental and inflicted pediatric head trauma. There is currently a disparity in the anecdotal case study literature as to what kinds of injuries can occur in children from low height falls. There is also a paucity of material property dat...

journal_title：Journal of neurotrauma

authors： Coats B,Margulies SS

更新日期：2006-08-01 00:00:00

abstract：:Optic nerve crush injury leads to death of retinal ganglion cells (RGCs), both as a direct result of the primary injury and via secondary degeneration induced by neurotoxins secreted by dying RGCs. Studies have shown that, if optic nerve crush is preceded by an unrelated injury to another part of the central nervous s...

journal_title：Journal of neurotrauma

authors： Ben Simon GJ,Hovda DA,Harris NG,Gomez-Pinilla F,Goldberg RA

更新日期：2006-07-01 00:00:00

abstract：:The neuroprotective effects of 17 beta -estradiol have been shown in models of central nervous system injury, including ischemia, brain injury, and more recently, spinal cord injury (SCI). Recent epidemiological trends suggest that SCIs in elderly women are increasing; however, the effects of menopause on estrogen-med...

journal_title：Journal of neurotrauma

authors： Chaovipoch P,Jelks KA,Gerhold LM,West EJ,Chongthammakun S,Floyd CL

更新日期：2006-06-01 00:00:00

abstract：:Severe traumatic brain injury (TBI) leads to an immunocompromised state responsible for an increased morbidity and mortality. Our understanding of the mechanisms responsible for this brain damage is incomplete. Damage maybe mediated by a complex cascade of neuroinflammation, and cytokine activation. In addition, trans...

journal_title：Journal of neurotrauma

authors： Mazzeo AT,Kunene NK,Gilman CB,Hamm RJ,Hafez N,Bullock MR

更新日期：2006-06-01 00:00:00

abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) has several different actions in the nervous system. Numerous studies have shown its neuroprotective effects both in vitro and in vivo. Previously, it has been demonstrated that PACAP reduces brain damage in rat models of global and focal cerebral ischemia. Ba...

journal_title：Journal of neurotrauma

authors： Tamás A,Zsombok A,Farkas O,Reglödi D,Pál J,Büki A,Lengvári I,Povlishock JT,Dóczi T

更新日期：2006-05-01 00:00:00

abstract：:Central nervous system (CNS) destruction in spinal cord injury (SCI) is caused by a complex series of cellular and molecular events. Recent studies have concentrated on signaling by receptors in the tumor necrosis factor receptor (TNFR) superfamily that mediate diverse biological outcomes ranging from inflammation to ...

journal_title：Journal of neurotrauma

authors： Keane RW,Davis AR,Dietrich WD

更新日期：2006-03-01 00:00:00

abstract：:Injured neurons in the mammalian central nervous system (CNS) do not normally regenerate their axons after injury. Neurotrauma to the CNS usually results in axonal damage and subsequent loss of communication between neuronal networks, causing long-term functional deficits. For CNS regeneration, repair strategies need ...

journal_title：Journal of neurotrauma

authors： Ruitenberg MJ,Vukovic J,Sarich J,Busfield SJ,Plant GW

更新日期：2006-03-01 00:00:00

abstract：:Although the citation index of an article is not a direct measure of its quality or importance, it is a measure of recognition that may suggest its impact on the scientific community. This study was undertaken to examine the characteristics of the top 100 most frequently cited articles (so-called "citation classics") ...

journal_title：Journal of neurotrauma

authors： Furlan JC,Fehlings MG

更新日期：2006-02-01 00:00:00

abstract：:The purpose of this study was to compare spontaneous functional recovery after different spinal motor tract lesions in the rat spinal cord using three methods of analysis, the BBB, the rope test, and the CatWalk. We transected the dorsal corticospinal tract (CSTx) or the rubrospinal tract (RSTx) or the complete dorsal...

journal_title：Journal of neurotrauma

authors： Hendriks WT,Eggers R,Ruitenberg MJ,Blits B,Hamers FP,Verhaagen J,Boer GJ

更新日期：2006-01-01 00:00:00

abstract：:Recommendations on treatment of patients with head injury were recently proposed by the National Institute for Clinical Excellence (NICE). We tested the clinical performance of NICE variables versus the proposal of the Neurotraumatology Committee of the World Federation of Neurosurgical Societies (NCWFNS). Over a 5-ye...

journal_title：Journal of neurotrauma

authors： Fabbri A,Servadei F,Marchesini G,Dente M,Iervese T,Spada M,Vandelli A

更新日期：2005-12-01 00:00:00

abstract：:Clinical trials aimed at developing therapies for traumatic brain injury (TBI) require outcome measures that are reliable, validated, and easily administered. The most widely used of these measures, the Glasgow Outcome Scale (GOS) and the GOS-Extended (GOS-E), have been criticized as suffering from ceiling effects. In...

journal_title：Journal of neurotrauma

authors： Hudak AM,Caesar RR,Frol AB,Krueger K,Harper CR,Temkin NR,Dikmen SS,Carlile M,Madden C,Diaz-Arrastia R

更新日期：2005-11-01 00:00:00

abstract：:It is now generally accepted that excitotoxic cell death involves bioenergetic failure resulting from the cycling of Ca2+ and the generation of reactive oxygen species (ROS) by mitochondria. Both Ca2+ cycling and ROS formation by mitochondria are dependent on the mitochondrial membrane potential (Deltapsi(m)) that res...

journal_title：Journal of neurotrauma

authors： Korde AS,Sullivan PG,Maragos WF

更新日期：2005-10-01 00:00:00

abstract：:Patients sustaining severe traumatic brain injury (TBI) have variable long-term outcomes. We examined the association between Glasgow Outcome Scale (GOS) assessed at 3 months and long-term outcomes at 12 months after TBI. We studied 159 patients with severe, closed traumatic brain injuries (Glasgow Coma Scale [GCS]

journal_title：Journal of neurotrauma

authors： King JT Jr,Carlier PM,Marion DW

更新日期：2005-09-01 00:00:00

abstract：:This study was designed to investigate the additional benefits of a multimodal early onset stimulation (MEOS) paradigm when combined with enriched environment (EE) versus EE only and standard housing (SH) on the recovery after experimental traumatic brain injury (TBI). Male Sprague- Dawley rats were subjected to moder...

journal_title：Journal of neurotrauma

authors： Maegele M,Lippert-Gruener M,Ester-Bode T,Sauerland S,Schäfer U,Molcanyi M,Lefering R,Bouillon B,Neiss WF,Angelov DN,Klug N,McIntosh TK,Neugebauer EA

更新日期：2005-07-01 00:00:00

abstract：:Information on the nature of deficits and adaptive mechanisms occurring after spinal cord injury is essential to the design of strategies for promoting functional recovery. Motor impairments and compensations were quantified by three-dimensional kinematic analysis in freely walking rats, 6 months after mild cervical (...

journal_title：Journal of neurotrauma

authors： Collazos-Castro JE,Soto VM,Gutiérrez-Dávila M,Nieto-Sampedro M

更新日期：2005-05-01 00:00:00

abstract：:A therapeutic strategy for acute spinal cord injury would be to reduce the progressive degeneration and disconnection of axons from their targets. Here, we describe a model to evaluate degeneration of the ascending sensory projections to the nuclei in the medulla following graded spinal cord contusions in adult female...

journal_title：Journal of neurotrauma

authors： Baker KA,Hagg T

更新日期：2005-04-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of death and functional disability in western countries, affecting mostly young patients. Despite intense and sustained efforts deployed for the development of new therapeutic strategies, no clinical benefit has been shown by any of the investigated compounds. Increasing...

journal_title：Journal of neurotrauma

authors： Soustiel JF,Palzur E,Nevo O,Thaler I,Vlodavsky E

更新日期：2005-03-01 00:00:00

abstract：:Protection against the progression of secondary injury appears to be an effective therapeutic strategy in spinal cord injury (SCI). Evidence indicates that nicotine can induce potent neuroprotective effects against injury to spinal cord neurons. Therefore, the present study was focused on the effects of nicotine on th...

journal_title：Journal of neurotrauma

authors： Ravikumar R,Fugaccia I,Scheff SW,Geddes JW,Srinivasan C,Toborek M

更新日期：2005-02-01 00:00:00

abstract：:Recently, locomotor training has been shown to improve overground locomotion in patients with spinal cord injury (SCI). This has triggered renewed interest in the role of exercise in rehabilitation after SCI. However, there are no mouse models for voluntary exercise and recovery of function following SCI. Here, we rep...

journal_title：Journal of neurotrauma

authors： Engesser-Cesar C,Anderson AJ,Basso DM,Edgerton VR,Cotman CW

更新日期：2005-01-01 00:00:00

abstract：:Prior studies have shown that neurons within the spinal cord are sensitive to response-outcome relations, a form of instrumental learning. Spinally transected rats that receive shock to one hind leg learn to maintain the leg in a flexed position that minimizes net shock exposure (controllable shock). Prior exposure to...

journal_title：Journal of neurotrauma

authors： Grau JW,Washburn SN,Hook MA,Ferguson AR,Crown ED,Garcia G,Bolding KA,Miranda RC

更新日期：2004-12-01 00:00:00

abstract：:It has been demonstrated that ethanol exerts dose-dependent effects, both beneficial and detrimental, on the outcome of traumatic brain injury (TBI). Recently, it has been reported that co-administration of caffeine (10 mg/kg) and a low amount of alcohol (0.65 g/kg; caffeinol) reduces cortical infarct volume up to 80%...

journal_title：Journal of neurotrauma

authors： Dash PK,Moore AN,Moody MR,Treadwell R,Felix JL,Clifton GL

更新日期：2004-11-01 00:00:00

abstract：:The purpose of this study was to investigate the potential neuroprotective efficacy of the mitochondrial uncoupler 2,4-dinitrophenol (DNP) in rats following a mild to moderate spinal cord contusion injury. Animals received intraperitoneal injections of vehicle (DMSO) or 5 mg/mL of DNP prior to injury. Twenty-four hour...

journal_title：Journal of neurotrauma

authors： Jin Y,McEwen ML,Nottingham SA,Maragos WF,Dragicevic NB,Sullivan PG,Springer JE

更新日期：2004-10-01 00:00:00

abstract：:Urokinase (uPA) and tissue plasminogen activator (tPA) are serine proteases implicated in fibrinolysis, but their role in the regulation of the cerebrovascular response to brain trauma has not been investigated. This study was designed to (1) characterize the cerebrovascular activity of uPA and tPA, (2) investigate th...

journal_title：Journal of neurotrauma

authors： Armstead WM,Cines DB,Al-Roof Higazi A

更新日期：2004-09-01 00:00:00

abstract：:Patients with spinal cord injury (SCI) typically experience body weight loss, motor function deficits, and a general decline of physical fitness. Animal models with these characteristics can serve to study the detailed adaptive changes following SCI. In the present study, we report the use of an adult paraplegic mouse...

journal_title：Journal of neurotrauma

authors： Landry E,Frenette J,Guertin PA

更新日期：2004-08-01 00:00:00

abstract：:Previous studies have resulted in conflicting results regarding the predictive effect of various clinical symptoms, signs, and plain imaging for intracranial pathology in adults with minor head injury. We sought to perform a meta-analysis of the literature to assess the significance of these factors for the prediction...

journal_title：Journal of neurotrauma

authors： Dunning J,Stratford-Smith P,Lecky F,Batchelor J,Hogg K,Browne J,Sharpin C,Mackway-Jones K,Emergency Medicine Research Group.

更新日期：2004-07-01 00:00:00

abstract：:Alterations in glutamatergic transmission are thought to contribute to secondary neuronal damage following traumatic brain injury. Using an in vitro cell injury model, we previously demonstrated an apparent reduction in AMPA receptor desensitization and resultant potentiation of AMPA-evoked currents after stretch inju...

journal_title：Journal of neurotrauma

authors： Goforth PB,Ellis EF,Satin LS

更新日期：2004-06-01 00:00:00

abstract：:Animals housed in an enriched environment develop thicker cortices, with increased numbers of dendrites, synapses, blood vessels, and glial cells. This study examines the responses of adult rats, developmentally reared in an enriched environment, to traumatic brain injury. Rats were placed in an enriched environment f...

journal_title：Journal of neurotrauma

authors： Kozlowski DA,Nahed BV,Hovda DA,Lee SM

更新日期：2004-05-01 00:00:00

abstract：:The Basso, Bresnahan and Beattie (BBB) locomotor scale has not been tested to evaluate functional consequences of peripheral nerve lesions. Alternative methods to evaluate animal functional recovery after sciatic nerve injury are desirable. Male Wistar rats had a right sciatic nerve segment exposed and were divided in...

journal_title：Journal of neurotrauma

authors： Schiaveto de Souza A,da Silva CA,Del Bel EA

更新日期：2004-05-01 00:00:00

abstract：:In this review we consider recovery of function after spinal cord injury, and, in particular, recovery improved following intraspinal cellular transplants. Some recovery occurs spontaneously and this can be especially dramatic in neonates, supporting the notion that developing and adult spinal cord respond differently...

journal_title：Journal of neurotrauma

authors： Murray M,Fischer I,Smeraski C,Tessler A,Giszter S

更新日期：2004-04-01 00:00:00

abstract：:It is the aim of the present paper to correlate clinical symptoms of auditory dysfunction (tinnitus, hyperacusis, hearing loss) one year on average after a blunt trauma of the head with objective audiological test results (otoacoustic emission and auditory brainstem response testing, impedance audiometry) and to compa...

journal_title：Journal of neurotrauma

authors： Nölle C,Todt I,Seidl RO,Ernst A

更新日期：2004-03-01 00:00:00

abstract：:The purpose of this study was to define the relationships among clinical characteristics of chronic pain, injury characteristics, affective factors and autonomic dysreflexia (AD) in people with chronic cervical spinal cord injury (SCI). A survey containing questions concerning the presence of AD, demographic factors, ...

journal_title：Journal of neurotrauma

authors： Widerström-Noga E,Cruz-Almeida Y,Krassioukov A

更新日期：2004-02-01 00:00:00

abstract：:Striking gender differences have been reported in the pathophysiology and outcome of acute neurological injury. Greater neuroprotection in females versus males may be due, in part, to direct and indirect sex hormone-mediated antioxidant mechanisms. Progesterone administration decreases brain levels of F(2)-isoprostane...

journal_title：Journal of neurotrauma

authors： Bayir H,Marion DW,Puccio AM,Wisniewski SR,Janesko KL,Clark RS,Kochanek PM

更新日期：2004-01-01 00:00:00